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妊娠期急性脂肪肝(AFLP)是妊娠晚期一种特发性的严重并发症,孕产妇及围产儿死亡率高。该病缺乏特异性临床表现,需与妊娠期肝内胆汁淤积症等相鉴别,早期易误诊。肝活检是诊断AFLP的金标准,但根据病史、临床表现结合实验室及影像学检查,不必肝脏穿刺也可以做出临床诊断。迅速终止妊娠并给予支持治疗是主要治疗措施,对改善AFLP患者母胎结局至关重要。
Acute fatty liver during pregnancy (AFLP) is an idiopathic and serious complication of late trimester with high maternal and perinatal mortality. The lack of specific clinical manifestations of the disease, the need to differentiate intrahepatic cholestasis of pregnancy and other phases, early misdiagnosis. Liver biopsy is the gold standard for the diagnosis of AFLP, but based on medical history, clinical manifestations combined with laboratory and imaging studies, it is also possible to make clinical diagnosis without liver puncture. Rapid termination of pregnancy and supportive care are the mainstay of treatment and are crucial to improving the outcome of the mothers in AFLP.