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目的探究与分析5,10-亚甲基四氢叶酸还原酶(MTHFR)及甲硫氨酸合成酶还原酶(MTRR)与不良孕产的相关性。方法选取该院2013年6月—2014年6月收治的有生育要求的育龄妇女120例,将其按照有无不良孕产史分为二组,每组各60例,分别为不良孕产组与正常组,对二组育龄妇女的MTHFR及MTRR基因多态性进行检测与分析。结果不良孕产组中未发生风险患者12例(20.00%),正常组未发生风险患者20例(33.33%),正常组较不良孕产组相比未发生风险患者明显增多(χ2=4.78,P<0.05);不良孕产组中高度风险患者23例(38.33%),正常组高度风险患者11例(18.33%),不良孕产组较正常组组相比高度风险患者明显增多(χ2=5.12,P<0.05)。二组低度风险相比差异无统计学意义(χ2=2.55,P>0.05);不良孕产组中度风险患者分别为15例(25.00%),正常组中度风险患者16例(26.67%),二组中度风险相比差异无统计学意义(χ2=2.72,P>0.05)。结论 MTHFR及MTRR基因多态性与不良孕产具有一定的相关性,临床工作者可针对诊断结果给予早期治疗,以降低不良孕产的发生率。
Objective To explore and analyze the relationship between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) and poor pregnancy. Methods 120 cases of reproductive age women of childbearing age who were admitted to our hospital from June 2013 to June 2014 were selected and divided into two groups according to whether there was any history of adverse pregnancy, 60 cases in each group And normal group, the two groups of women of childbearing age MTHFR and MTRR gene polymorphism were detected and analyzed. Results There were 12 patients (20.00%) in the unfavorable pregnancy group and 20 patients (33.33%) in the normal group without risk. The patients in the normal group were significantly higher than those in the non-pregnant group (χ2 = 4.78, 23 (38.33%) were in high risk group, 11 in high risk group (18.33%) in normal group, and significantly higher in high risk group than in normal group (χ2 = 5.12, P <0.05). There was no significant difference between the two groups in low risk (χ2 = 2.55, P> 0.05); moderate risk patients in adverse pregnancy group were 15 cases (25.00%), moderate risk group in normal group was 16 cases (26.67% ), There was no significant difference between the two groups in moderate risk (χ2 = 2.72, P> 0.05). Conclusion MTHFR and MTRR gene polymorphisms are associated with adverse pregnancy. Clinicians may give early treatment based on the diagnostic results to reduce the incidence of adverse pregnancy.