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目的探讨尘肺人群累积粉尘暴露量(cumulative silica dust exposure,CDE)和反射波增强指数(augmentation index,AI)的关系。方法将2014年3月-2015年8月参加康复治疗的618例尘肺患者作为研究对象,根据尘肺患者CDE四分位数将研究对象分为第1分位组(CDE≤877 mg/(m~3·a),n=149人),第2分位组(877≤CDE≤1 105 mg/(m~3·a),n=158人),第3分位组(1 105≤CDE≤1 320 mg/(m~3·a),n=163人),第4分位组(CDE≥1 320 mg/(m~3·a),n=148人)。比较不同粉尘暴露量AI的差异。结果CDE与AI呈正相关(P<0.05)。校正了年龄、心率(HR)、体质量指数(BMI)、超敏C反应蛋白(hypersensitive C-reactive protein,hs CRP)、甘油三酸酯(triglyceride,TG)、低密度脂蛋白(low density lipoprotein,LDL)、糖尿病、高血压病、吸烟等因素后,与第2分位组比较,第1、3、4分位组的AI≥11.6的检出率逐步增加,Ptrend=0.041。结论尘肺人群CDE与反射波AI呈正相关,粉尘暴露量增加是动脉硬化的危险因素。
Objective To investigate the relationship between cumulative silica dust exposure (CDE) and augmentation index (AI) in patients with pneumoconiosis. Methods A total of 618 patients with pneumoconiosis who participated in rehabilitation from March 2014 to August 2015 were enrolled in this study. According to the CDE quartiles of patients with pneumoconiosis, the subjects were divided into the first quintile (CDE≤877 mg / (m ~ 3 · a), n = 149), placebo group 2 (877≤CDE≤1 105 mg / (m ~ 3 · a), n = 158) 1 320 mg / (m 3 · a), n = 163), and in the 4th subgroup (CDE ≥1 320 mg / (m 3 · a), n = 148). Compare the difference of AI of different dust exposure. Results CDE was positively correlated with AI (P <0.05). (HR), body mass index (BMI), hypersensitive C-reactive protein (hs CRP), triglyceride (TG), low density lipoprotein , LDL, diabetes mellitus, hypertension, smoking and other factors, the detection rate of AI≥11.6 in the 1st, 3rd, 4th, and 4ths interquartilely increased gradually compared with that in the second interquartile range (Ptrend = 0.041). Conclusion The CDE of pneumoconiosis patients is positively correlated with the reflex wave AI. The increased dust exposure is a risk factor for atherosclerosis.