目的探讨血液灌流用于重度有机磷农药中毒治疗的临床效果。方法将60例重度有机磷农药中毒患者随机分为两组,对照组予以洗胃、导泻、补液、机械通气等常规治疗,治疗组在对照组基础上予以血液灌流治疗。结果治疗组阿托品用量明显少于对照组、阿托品化时间明显短于对照组(P<0.05),治疗组胆碱酯酶、意识恢复时间均明显短于对照组(P<0.05)。结论常规治疗方式联合血液灌流可加快患者意识与胆碱酯酶恢复、减少阿托品用量,提升综合治疗效果。 Objective To investigate the clinical effect of hemoperfusion on severe organophosphorus pesticide poisoning. Methods Sixty patients with severe organophosphorus pesticide poisoning were randomly divided into two groups. The control group was given routine treatment such as gastric lavage, catharsis, rehydration and mechanical ventilation. The treatment group was given hemoperfusion on the basis of the control group. Results The dosage of atropine in the treatment group was significantly less than that in the control group, and the time of atropineization was significantly shorter than that of the control group (P <0.05). The cholinesterase and consciousness recovery time in the treatment group were significantly shorter than those in the control group (P <0.05). Conclusion Conventional treatment combined with hemoperfusion can speed up the patient awareness and recovery of cholinesterase, reduce the amount of atropine, and enhance the comprehensive treatment effect.