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正常胃肠道、乳腺、胰腺、输尿管、卵巢等上皮性细胞中,有一层保护性的黏液层,起到防止上皮细胞的损伤和润滑作用,黏液层主要的成分是黏蛋白(Mucins,MUC)。MUC不仅在正常细胞中具有重要作用,在上皮性肿瘤中MUC常出现异常表达,并与肿瘤的侵袭、转移等生物行为相关,MUC家族部分成员作为肿瘤相关抗原已经应用于肿瘤的免疫治疗和肿瘤标志物。1 MUC的结构与功能MUC是一种大分子量糖蛋白家族,高度糖基
Normal mucosa of the gastrointestinal tract, breast, pancreas, ureter, ovary and other epithelial cells, there is a protective layer of mucus to prevent damage and lubrication of epithelial cells, the main component of the mucus layer is mucin (Mucins, MUC) . MUC not only plays an important role in normal cells, but MUC is often expressed abnormally in epithelial tumors and is associated with biological behaviors such as invasion and metastasis of tumor. Some members of MUC family have been used as tumor-associated antigens in immunotherapy of tumors and tumors landmark. 1 MUC structure and function MUC is a large molecular weight glycoprotein family, a high degree of glycosylation