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目的分析孕期妇女百日咳毒素(PT)IgG抗体水平,并评价近期感染百日咳的可能。方法采用定量ELISA方法检测154例健康孕期妇女怀孕初期以及怀孕后期双份血清PT-IgG。结果所有标本PT-Ig G均<100 IU/ml,其中72例(46.8%)受试者在临产前PT-IgG<5 IU/ml。4例受试者的双份血清PT-IgG滴度发生2倍以上的下降。估算孕期妇女近期的百日咳年感染率为4.5%(365.25/208.9×2.6%)。结论孕期妇女的PT-IgG滴度较低,成年育龄妇女在怀孕前可能自然感染百日咳,其感染率可能被低估。
Objective To analyze the levels of pertussis toxin (PT) IgG antibody in pregnant women and evaluate the possibility of recent infection with whooping cough. Methods Quantitative ELISA was used to detect the serum levels of PT-IgG in 154 pregnant women during the first trimester of pregnancy and the second trimester of pregnancy. Results All samples had PT-Ig G <100 IU / ml, of which 72 (46.8%) had PT-IgG <5 IU / ml before labor. Four subjects had double serum PT-IgG titer more than doubled. The estimated annual prevalence of pertussis in pregnant women was 4.5% (365.25 / 208.9 × 2.6%). Conclusions Pregnant women have low PT-IgG titer. Women of childbearing age may naturally be infected with whooping cough before pregnancy, and the infection rate may be underestimated.