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目的:探讨围绝经期雌激素水平与支气管哮喘的关系。方法:选择21例42~54岁围绝经期女性支气管哮喘患者作为观察组,行肺功能、峰值流速变异率、支气管舒张试验等检查,并测定雌二醇及促卵泡成熟素水平;另选择18例健康围绝经期妇女作为对照组,行肺功能、雌二醇及促卵泡成熟素测定。结果:观察组血中雌二醇水平显著低于对照组。结论:围绝经期雌激素水平的降低与支气管哮喘发病可能相关。
Objective: To investigate the relationship between estrogen level in perimenopausal period and bronchial asthma. Methods: Twenty-one female perimenopausal women aged 42-54 years were selected as the observation group. The lung function, peak flow rate variability, bronchial dilation test and other tests were performed to determine the estradiol and follicle-stimulating hormone levels. Another 18 Cases of healthy perimenopausal women as a control group, lung function, estradiol and follicle-stimulating hormone determination. Results: The estradiol level in the observation group was significantly lower than that in the control group. Conclusion: The reduction of estrogen level in perimenopausal women may be related to the pathogenesis of bronchial asthma.