A structural analysis of the International Thermonuclear Experimental Reactor(ITER) vacuum vessel’s lower port region was presented by means of a finite element analysismethod.The purpose is to evaluate the stress and displacement level on this structure undervarious combinations of five designed loads,including the gravity of the vacuum vessel,seismicloads,electromagnetic loads,and possible pressure loads to ensure structural safety.The cyclicsymmetry finite element model of this structure was developed by using ANSYS code.The re-sults showed that the maximum stress does not exceed the allowable value for any of the loadcombinations according to ASME code and the nine vacuum vessel (VV) supports have the abilityto sustain the entire VV and in vessel-components and withstand load combinations under bothnormal as well as off-normal operation conditions.Stress mainly concentrates on the connectingregion of the VV support and lower port stub extension. A structural analysis of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel’s lower port region was presented by means of a finite element analysis method. The purpose is to evaluate the stress and displacement level on this structure under varying combinations of five designed loads, including the gravity of the vacuum vessel, seismicloads, electromagnetic loads, and possible pressure loads to ensure structural safety.The cyclicsymmetry finite element model of this structure was developed by using ANSYS code.The re sults showed that the maximum stress does not exceed the allowable value for any of the loadcombinations according to ASME code and the nine vacuum vessel (VV) supports have the ability to sustain the entire VV and in vessel-components and withstand load combinations under both normal and well as off-normal operation conditions. of the VV support and lower port stub extension.