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目的:探讨左旋甲状腺素对亚临床甲减、临床甲减患者疗效及血脂水平的影响。方法:选择临床甲减患者60例(临床甲减组)和亚临床甲减患者60例(亚临床甲减组)。两组患者口服左旋甲状腺素钠1μg/(kg·d),疗程为12周。疗程结束后,给予维持量服药。观察两组治疗前后血脂水平改变情况。结果:临床甲减组治疗后TC下降幅度显著高于亚临床甲减组,差异有统计学意义(P<0.05);临床甲减组和亚临床甲减组治疗后LDL水平分别与本组内治疗前比较,差异有统计学意义(P<0.05)。结论:左旋甲状腺素治疗亚临床甲减、临床甲减患者能够改善临床症状,且能改善患者的血脂情况。
Objective: To investigate the effects of levothyroxine on the efficacy of subclinical hypothyroidism and clinical hypothyroidism and blood lipid levels. Methods: 60 patients with clinical hypothyroidism (clinical hypothyroidism) and 60 patients with subclinical hypothyroidism (subclinical hypothyroidism) were selected. Two groups of patients oral levothyroxine sodium 1μg / (kg · d), the course of 12 weeks. After the end of treatment, given to maintain the amount of medication. The changes of blood lipid level before and after treatment were observed. Results: The TC reduction in clinical hypothyroidism group was significantly higher than that in subclinical hypothyroidism group (P <0.05). The levels of LDL in clinical hypothyroidism group and subclinical hypothyroidism group were significantly lower than those in subclinical hypothyroidism group Before treatment, the difference was statistically significant (P <0.05). Conclusion: L-thyroxine treatment of subclinical hypothyroidism, clinical hypothyroidism patients can improve clinical symptoms, and can improve the patient’s blood lipids.