Worsening of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio i

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Dear Editor,rnProstate cancer (PCa) is the most frequently diagnosed male cancer in Western countries,and the number of PCa patients is also rapidly increasing in Japan.1,2 Simultaneously,androgen deprivation therapy (ADT) has also been increasingly used in PCa patients in recent years.3-5 However,the long-term use of ADT is associated with a variety of pivotal adverse events,including diabetes,anemia,osteoporosis,serum lipid profile changes,and cardiovascular disease (CVD).1,2Higher low-density lipoprotein cholesterol (LDL-C) and/or lower high-density lipoprotein cholesterol (HDL-C) are well-established risk factors for CVD,and control of their levels has been an important goal in the treatment and prevention of CVD.6,7
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