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目的:建立小针剂配伍输液中细菌内毒素的含量分析方法,减少临床热原反应的发生。方法:采用中国药典2005年版二部动态浊度法检测混合药液中细菌内毒素的含量,并对18组临床输液残液进行检测。结果:混合药液经稀释后能排除干扰。结论:动态浊度法测定此类混合药液中细菌内毒素含量是可行的。
OBJECTIVE: To establish a method for the analysis of bacterial endotoxin in the small infusion and infusion solution to reduce the occurrence of clinical pyrogen reaction. Methods: The content of bacterial endotoxin in the mixed liquid was measured by two dynamic nephelometry methods of 2005 edition of Chinese Pharmacopoeia, and 18 clinical liquid infusion residues were tested. Results: After dilution, the mixed solution can eliminate the interference. Conclusion: It is feasible to determine the bacterial endotoxin content in such liquid mixture by dynamic turbidity method.