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目的探讨2型糖尿病(T2DM)患者皮质醇分泌和下丘脑-垂体-肾上腺(HPA)轴活性的改变。方法选取2型糖尿病患者114例(T2DM组)和17例单纯向心性肥胖患者、正常对照80名(NC组),T2DM组再按腰围分为肥胖组和非肥胖组,比较4组皮质醇分泌水平和HPA轴活性。结果 4组患者皮质醇基础水平无差异;用地塞米松后T2DM+OB组女性患者皮质醇被抑制程度较NC组少(P<0.05);与T2DM+OB组、NC组比较,T2DM组患者肾上腺被兴奋程度最高,尤其在男性(P<0.05)。结论不同体脂分布、不同性别T2DM患者存在HPA轴活性的差异。
Objective To investigate the changes of cortisol secretion and hypothalamic-pituitary-adrenal (HPA) axis activity in patients with type 2 diabetes mellitus (T2DM). Methods Totally 114 patients with type 2 diabetes mellitus (T2DM group) and 17 patients with simple concentric obesity were enrolled in the study. Eighty normal controls (NC group) were divided into obesity group and non-obese group according to waist circumference. Level and HPA axis activity. Results There was no difference in basal level of cortisol among the four groups. The degree of inhibition of cortisol in T2DM + OB group was less than that in NC group (P <0.05). Compared with T2DM + OB group and NC group, Was the most excited, especially in males (P <0.05). Conclusion There is difference of HPA axis activity in different body fat distribution and different sex T2DM patients.