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目的探讨溶血磷脂酸、人附睾蛋白4和CA125联检对卵巢癌诊断的应用价值。方法测定卵巢癌患者134例、卵巢良性肿瘤患者93例及30例健康妇女的血LPA、HE4水平,同时测定卵巢癌患者CAl25含量,并作对比分析。结果卵巢癌患者LPA、HE4的水平明显高于卵巢良性肿瘤患者及健康妇女(P<0.05),后两者LPA、HE4的水平无统计学意义。LPA、HE4和CA125对卵巢癌诊断的敏感性和特异性分别为85.4%、82.3%和77.8%、91.6%及67.6%、77.3%。结论 LPA、HE4单项检测诊断卵巢恶性肿瘤的特异性优于CA125单项检测,三者联合检测可以提高诊断能力。
Objective To investigate the diagnostic value of lysophosphatidic acid, human epididymal protein 4 and CA125 in the diagnosis of ovarian cancer. Methods The levels of LPA and HE4 in 134 cases of ovarian cancer, 93 cases of benign ovarian tumors and 30 healthy women were determined. The levels of CA125 in ovarian cancer patients were also determined and compared. Results The levels of LPA and HE4 in patients with ovarian cancer were significantly higher than those in patients with benign ovarian tumors and healthy women (P <0.05). The levels of LPA and HE4 in the latter two patients were not statistically significant. The sensitivity and specificity of LPA, HE4 and CA125 for the diagnosis of ovarian cancer were 85.4%, 82.3% and 77.8%, 91.6% and 67.6%, 77.3%, respectively. Conclusions The specificity of single detection of LPA and HE4 in the diagnosis of ovarian cancer is better than the single detection of CA125. The combined detection of LPA and HE4 can improve the diagnostic ability.