论文部分内容阅读
全身性化疗对白血病的脊髓和颅内浸润收效甚微,因而联合氨甲喋呤(MTX)或其他制剂的鞘内注射已被广泛采用。本文报告一例急性白血病儿童,在全身化疗同时进行了预防性鞘内MTX治疗。在白血病完全缓解后,发生了进行性弛缓性瘫痪和脑症状。患儿未进行过脑部放射治疗,临床和病解均无中枢神经系统白血病的证据,故其中枢神经系统损害可能仅仅是MTX的毒性作用所致。作者指出,MTX鞘内治疗引起象本例这样的广泛性损害尚无报告。MTX引起脑脊髓的各种形式损害的发病机理尚未明白。可能与多种因素有关,例
Systemic chemotherapy for leukemia with little effect of spinal cord and intracranial infiltration, and thus combined with methotrexate (MTX) or other agents intrathecal injection has been widely used. This article reports a case of acute leukemia in children with systemic intrathecal prophylactic intrathecal MTX treatment. After complete remission of leukemia, progressive flaccid paralysis and brain symptoms occurred. Children with no brain radiation therapy, clinical and disease solutions were no evidence of central nervous system leukemia, so its central nervous system damage may be caused only by the toxic effects of MTX. The authors note that there is no report of extensive damage such as this case caused by intrathecal treatment of MTX. The pathogenesis of various forms of damage to the brain caused by MTX is unknown. May be related to a variety of factors, for example