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目的探讨尿激酶对急性心肌梗死患者心肌耗氧量与肌酸磷酸激酶(CK)及心电图变化的影响。方法选取收治的急性心肌梗死患者84例,按随机数表法分为两组,各42例。对照组实施常规治疗,观察组在对照组基础上加用尿激酶进行治疗,比较两组心率、血压、心肌耗氧量、CK值、心电图ST段变化率及血管再通率。结果治疗后,观察组心率及心肌耗氧量较对照组明显降低,差异显著(P<0.05);起病后16h及24h,观察组CK值较对照组明显降低,心电图ST段变化率及血管再通率较对照组明显提高,差异显著(P<0.05)。结论尿激酶治疗急性心肌梗死患者效果较好,可改善患者心肌耗氧量、CK值及心电图ST段变化率,促进血管再通率提高。
Objective To investigate the effect of urokinase on myocardial oxygen consumption and creatine phosphokinase (CK) and electrocardiogram (ECG) in patients with acute myocardial infarction. Methods Eighty-four patients with acute myocardial infarction who were admitted to our hospital were divided into two groups (n = 42) according to random number table. The control group was given routine treatment. The observation group was treated with urokinase on the basis of the control group. The heart rate, blood pressure, myocardial oxygen consumption, CK value, ECG ST segment change rate and recanalization rate were compared between the two groups. Results After treatment, heart rate and myocardial oxygen consumption in the observation group were significantly lower than those in the control group (P <0.05); CK values in the observation group were significantly lower than those in the control group at 16 h and 24 h after onset Recanalization rate was significantly higher than the control group, the difference was significant (P <0.05). Conclusions Urokinase treatment of patients with acute myocardial infarction better effect, can improve myocardial oxygen consumption, CK value and ECG ST segment rate of change, and promote the rate of recanalization.