目的　观察乙肝病毒血清标志 (HBVM)阳性淋巴瘤患者化疗所致肝功能损害情况。方法　HBVM阳性淋巴瘤患者 336例 ,化疗 2周后测肝功能 ,包括ALT、AST、ALP、GGT及TBIL ,对照组为 119例HBVM阴性淋巴瘤患者。结果　HBVM阳性组肝功能异常占 38.39% ,显著高于对照组 19.33 % ,(P <0 .0 1)。结论　HBVM阳性淋巴瘤患者化疗时较易出现肝功能损害 Objective To observe the liver damage caused by chemotherapy in patients with positive hepatitis B virus (HBVM) positive lymphoma. Methods A total of 336 patients with HBVM positive lymphoma were enrolled. Two weeks after the chemotherapy, liver function, including ALT, AST, ALP, GGT and TBIL, were measured. The control group was 119 HBVM negative lymphoma patients. Results The abnormal liver function in HBVM positive group was 38.39%, which was significantly higher than that in control group (19.33%, P <0.01). Conclusions Patients with HBVM positive lymphoma are more likely to have liver damage during chemotherapy