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Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane (1)and 6α, 15β-epoxy eremophila-7(11)-en-8α, 12-olide (2) were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.