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[目的]观察复方甘草酸苷联合丹参注射液对酒精性肝病(ALD)患者血清肿瘤坏死因子α(TNF-α)及瘦素(Leptin)的影响。[方法]将120例ALD患者随机分为对照组、复方甘草酸苷(甘草酸苷)组、丹参组及复方甘草酸苷联合丹参(联合)组,各30例,治疗30 d后观察血清肝纤维化指标、Leptin及TNF-α水平。[结果]各组治疗后血清肝纤维化指标、TNF-α及Leptin较治疗前均显著下降(P<0.05),联合组较对照组、甘草酸苷组及丹参组均显著下降(P<0.05)。[结论]复方甘草酸苷联合丹参注射液能够显著降低ALD患者血清TNF-α及Leptin水平。
[Objective] To observe the effects of compound glycyrrhizin combined with Danshen injection on serum tumor necrosis factor-α (TNF-α) and leptin in patients with alcoholic liver disease (ALD). [Methods] 120 patients with ALD were randomly divided into control group, compound glycyrrhizin (glycyrrhizin) group, salvia miltiorrhiza group, compound glycyrrhizin and salvia miltiorrhiza (combined) group, 30 cases each, and serum liver was observed after 30 days of treatment. Fibrosis markers, Leptin, and TNF-α levels. [Results] Serum hepatic fibrosis indexes, TNF-α and Leptin were significantly decreased after treatment in each group (P<0.05), and the combination group was significantly lower than the control group, glycyrrhizin group and Danshen group (P<0.05). ). [Conclusion] Compound glycyrrhizin and Salvia miltiorrhiza injection can significantly reduce serum TNF-α and Leptin levels in patients with ALD.