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目前帕金森病(PD)的诊断仅依靠临床特征而缺乏相应的辅助检查方法。近年来,大量研究评估了影像学、药物试验、生化标志物及基因检测等对PD的诊断意义,其中外周体液标志物研究因其适用范围广,方便、创伤小、直接反应病理过程等特点得到重视。本文就α突触核蛋白、线粒体复合物Ⅰ和氧化应激以及多巴胺在该方面的相关研究予以综述。
The current diagnosis of Parkinson’s disease (PD) depends only on clinical features and the lack of appropriate laboratory examinations. In recent years, a large number of studies have evaluated the diagnostic significance of imaging, drug testing, biochemical markers and genetic testing on PD, among them the study of peripheral body fluid markers has been widely applied because of its wide range of application, convenience, less trauma and direct reaction pathological process Pay attention. This article reviews the related studies of α-synuclein, mitochondrial complex Ⅰ and oxidative stress and dopamine in this aspect.