为了探讨预防型抗氟剂 (Ⅰ型 - 1)的遗传毒性 ,选用雄性昆明种小白鼠 30只 ,随机分为阴性对照组、低、中、高剂量组 (剂量分别为 2 0 0 ,40 0 ,80 0mg/kg)、阳性对照组 (环磷酰胺 5 0mg/kg) 。剂量组灌胃 ,每天一次 ,连续 5天。断头取血 ,进行微核试验和单细胞凝胶电泳实验 (SCGE)。结果表明 ,剂量组不但微核率较低 ,而且也未出现彗星。提示 ,预防型抗氟剂 (Ⅰ型 - 1)在 2 0 0～ 80 0mg/kg 剂量范围内对小鼠无遗传毒性 In order to investigate the genotoxicity of prophylactic antifiuoric agent (Ⅰ-1), 30 male Kunming mice were randomly divided into negative control group, low, medium and high dose groups (doses of 200, 40 0 , 80 0mg / kg), positive control group (cyclophosphamide 50mg / kg). Dose group gavage once a day for 5 days. Blood was decapitated and subjected to micronucleus test and single cell gel electrophoresis test (SCGE). The results showed that the dose group not only low micronucleus rate, but also did not comet. Tip, prophylactic anti-fluoride agent (type 1 -) in the 200 ~ 80 0mg / kg dose range of mice without genotoxicity