论文部分内容阅读
联苯并环辛二烯类木脂素是重要的一类天然产物,具有保肝等多种生物活性.近20余年来各国学者对其全合成研究进行了卓有成效的探索,尤其在芳基氧化偶联试剂的应用方面取得了很多进展.作者结合在该领域多年的工作积累,对分子内和分子间芳基氧化偶联试剂在联苯并环辛二烯木脂素合成中的应用及全合成研究的进展进行了综述,以便对同道起到参考与启发作用.最后提出了新的双片段合成拼接的设想.
Biphenylcyclopentadienyl lignans are important natural products with many bioactivities such as hepatoprotection.More than 20 years scholars from all over the world have made fruitful explorations on their total synthesis, The application of coupling reagent has made a lot of progress.The author combined with the accumulation of many years of work in this field, the application of intramolecular and intermolecular aryl oxidative coupling reagents in the synthesis of biphenyl-cyclooctadiene lignan The progress of synthesis is reviewed in order to play a reference and enlightenment for the same people.Finally, a new idea of bi-segment synthesis is proposed.