同型半胱氨酸(Hcy)一直被视为心血管疾病的一个独立危险因素,但近年来的研究发现高Hcy很可能不是引起血管损伤的真正致病因素,而只是一个伴随现象。Hcy的前体物质S-腺苷同型半胱氨酸(SAH)可由Hcy逆向合成,SAH升高能诱导血管内皮细胞的损伤,参与动脉粥样硬化的形成,其机制与抑制DNA甲基化有关。SAH可能是较Hcy更敏感的预测心血管疾病风险的指标。 Hcy has long been considered as an independent risk factor for cardiovascular disease. However, recent studies have found that high Hcy may not be the real cause of vascular injury, but only a companion phenomenon. Hcy precursors S-adenosylhomocysteine ​​(SAH) reverse synthesis by Hcy, SAH can induce vascular endothelial cell injury, involved in the formation of atherosclerosis, its mechanism and inhibition of DNA methylation. SAH may be a more sensitive predictor of cardiovascular disease than Hcy.