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糖尿病血管并发症是糖尿病的主要致残及致死原因。流行病学调查资料表明,糖尿病患者发生动脉粥样硬化及危及生命的心血管并发症的危险性较常人增加3～4倍,而糖基化终产物(AGEs)对糖尿病血管并发症的发生和发展起重要作用。本文主要对AGEs及其受体途径在糖尿病血管并发症中的作用及其相关的药物治疗研究进展做一综述。一、AGEs、AGEs受体及其生物学作用 AGEs是葡萄糖或其他还原糖与蛋白质、脂肪或核酸末
Diabetic vascular complications are major causes of disability and death of diabetes. Epidemiological survey data show that diabetic patients with atherosclerosis and life-threatening cardiovascular complications than the average risk increased 3 to 4 times, and advanced glycation end products (AGEs) on the occurrence of diabetic vascular complications and Development plays an important role. This article mainly reviews the role of AGEs and its receptor pathway in diabetic vascular complications and its related research progress in drug treatment. A, AGEs, AGEs receptors and their biological role AGEs is glucose or other reducing sugars and proteins, fat or nucleic acid at the end