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目的:探讨纤维支气管镜刷片(bronchofiberscopic(BFS)washing cytology,BWC)液基细胞学检测(Liquid-based Cytology test,LCT)在肺癌诊断中的价值。方法:收集同时进行LCT和传统涂片检查的纤支镜刷片的病例543例,分析LCT和传统涂片对肺癌诊断的敏感度,特异性和分型的准确性。结果:LCT和传统涂片法诊断肺癌的敏感度分别为87.2%和81.8%,差异有统计学意义(P<0.05)。特异性分别为91.2%和94.8%,差异无统计学意义(P>0.05)。细胞学分型诊断与组织学的符合率,在LCT中,鳞癌为94.4%,腺癌95.7%,小细胞癌90.9%,总符合率为93.4%。结论:LCT是在支气管刷检制片,染色等方面便于实施质量控制的一项新技术,在肺癌诊断中具有较高的敏感度和分型诊断符合率。
Objective: To investigate the value of liquid-based cytology test (LCT) in the diagnosis of lung cancer by bronchofiberscopic (BFS) washing cytology (BWC). Methods: A total of 543 cases of bronchoscopic brush with LCT and traditional smears were collected. The sensitivity, specificity and accuracy of LCT and traditional smears for the diagnosis of lung cancer were analyzed. Results: The sensitivities of LCT and traditional smears in diagnosing lung cancer were 87.2% and 81.8%, respectively, with statistical significance (P <0.05). The specificity was 91.2% and 94.8% respectively, with no significant difference (P> 0.05). In LCT, squamous cell carcinoma was 94.4%, adenocarcinoma 95.7%, small cell carcinoma 90.9%, and the total coincidence rate was 93.4%. CONCLUSION: LCT is a new technique that is convenient for quality control in bronchial brushing, staining and other aspects. It has high sensitivity and good coincidence rate in diagnosis of lung cancer.