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Objective:It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control.Therefore,we investigated the effects of royal jelly supplementation in diabetic females.Methods:In this pilot,parallel design randomized clinical trial,50 female volunteers with type2 diabetes were randomly allocated to the supplemented(25,cases)and placebo(25,cases)groups,based on random block procedure produced by Random Allocation Software,given a daily dose of 1,000 mg royal jelly soft gel or placebo,respectively,for 8 weeks.Before and after intervention,glycemic control indices,antioxidant and oxidative stress factors were measured.Results:After royal jelly supplementation,the mean fasting blood glucose decreased remarkably(163.05142.51 mg/dL vs.149.68±42.7 mg/dL).Royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels(8.67%±2.24%vs.7.05%±1.45%,P=0.001)and significant elevation in the mean insulin concentration(70.28±29.16 pmol/L vs.86.46±27.50 pmol/L,P=0.01).Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels(P<0.05).At the end of study,the mean total antioxidant capacity elevated insignificantly in both groups.Conclusions:On the basis of our findings,it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes.Further studies with larger sample size are warranted.
Objective: It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Herefore, we investigated the effects of royal jelly supplementation in diabetic females. Methods: In this pilot, parallel design randomized clinical trial, 50 female volunteers with type 2 diabetes were randomly allocated to the supplemented (25, cases) and placebo (25, cases) groups, based on random block procedure produced by Random Allocation Software, given a daily dose of 1,000 mg royal jelly soft gel or placebo, respectively, Results: After royal jelly supplementation, the mean fasting blood glucose decreased remarkably (163.05142.51 mg / dL vs. 149.68 ± 42.7 mg / ). Royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels (8.67% ± 2.24% vs 7.05% ± 1.45%, P = 0.001) and significant elevation in the mean insuli Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels (P <0.05). At the end of study, the (n = 70.28 ± 29.16 pmol / L vs 0.86.46 ± 27.50 pmol / L, mean total antioxidant capacity elevated insignificantly in both groups. Conclusions: On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling for diabetes outcomes.Further studies with larger sample size are warranted.