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近年来,越来越多的研究表明在肿瘤干细胞(cancer stem cell,CSC)中存在着许多复杂的分子信号通路。本文主要介绍几条目前研究较为透彻的干细胞内信号通路,并对已知通路之间存在的蛋白质串流(cross-talk)的相关研究作简要阐述。同时,在肿瘤治疗中选择靶向肿瘤干细胞信号通路,调控通路中某些特异性蛋白质的表达,亦将为肿瘤临床治疗提供一条全新的思路。
In recent years, more and more studies indicate that there are many complex molecular signaling pathways in cancer stem cells (CSCs). This article describes several well-studied current stem cell signaling pathways and briefly describes the related research on the protein cross-talk that exists between known pathways. At the same time, it is a new idea for clinical treatment of tumors to select the target-directed cancer stem cell signaling pathway and regulate the expression of certain specific proteins in tumor therapy.