目的:探究温肺止流丹加减联合糠酸莫米松鼻喷剂治疗慢性鼻-鼻窦炎的临床疗效及安全性。方法:抽取2018年1月至2020年1月于漯河市中医院就诊的慢性鼻-鼻窦炎患者92例，按照随机数字表法分为观察组和对照组，每组46例。对照组采用糠酸莫米松鼻喷剂治疗，观察组在此基础上联合温肺止流丹加减汤，比较两组临床疗效，比较两组治疗前后的症状视觉模拟量表(VAS)评分、Lund-Mackey评分、Lund-Kennedy评分、鼻腔鼻窦结局测试-20(SNOT-20)评分，白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平，比较两组治疗期间不良反应发生情况。结果:治疗后，观察组总有效率为80.43%(37/46)，对照组为60.87%(28/46)，差异有统计学意义(n P<0.05)。治疗后，两组嗅觉减退、头痛、鼻塞、流涕的VAS评分均较治疗前下降，且观察组低于对照组(n P<0.05)；两组Lund-Mackey、Lund-Kennedy、SNOT-20评分均较治疗前下降，且观察组低于对照组(n P<0.05)；两组IL-6、IL-17、TNF-α水平均较治疗前下降，且观察组低于对照组(n P0.05)。n 结论:采用温肺止流丹加减联合糠酸莫米松鼻喷剂治疗慢性鼻-鼻窦炎疗效好，能有效改善患者临床症状及炎性因子水平，且安全性较好。“,”Objective:To investigate the clinical effect and safety of modified Wenfei Zhiliu pellet combined with mometasone furoate nasal spray in the treatment of chronic rhinosinusitis (CRS).Methods:A total of 92 CRS patients who were treated in the Traditional Chinese Medicine Hospital of Luohe from January 2018 to January 2020 were enrolled. They were divided into observation group and control group by random number table method, with 46 cases in each group. The control group was treated with mometasone furoate nasal spray, while observation group was treated with modified Wenfei Zhiliu pellet based on the treatment of control group. The clinical curative effect, scores of visual analogue scale (VAS) score, Lund-Mackey score, Lund-Kennedy score, SNOT-20 score, levels of interleukin-6 (IL-6), interleukin-17 (IL-17) and tumor necrosis factor-α(TNF-α) before and after treatment, and incidence of adverse reactions during treatment were compared between the two groups.Results:After treatment, the total effective rate was 80.43% (37 / 46) in the observation group, and 60.87% (28/46) in the control group, and the difference between the two groups was statistically significant (n P<0.05). After treatment, VAS scores in terms of hyposmia, headache, nasal congestionand runny nose decreased in both groups, and these scores in the observation group were lower than those in the control group (n P<0.05). After treatment, the scores of Lund-Mackey, Lund-Kennedy and SNOT-20 decreased in both groups, and those in the observation group were lower than those in the control group (n P<0.05). During treatment, levels of IL-6, IL-17 and TNF-α were lower than those before treatment in both groups, and those in the observation group were lower than those in the control group (n P0.05.n Conclusions:The curative effect of modified Wenfei Zhiliu pellet combined with mometasone furoate nasal spray on CRS is good, which can effectively improve clinical symptoms and levels of inflammatory factors, with good safety.