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C1q/肿瘤坏死因子相关蛋白12(CTRP12)是近年新发现的一种与脂联素高度同源的脂肪因子,主要作用于脂肪组织和肝脏。CTRP12可分别通过增强胰岛素信号和直接激活磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)信号通路抑制糖异生、促进葡萄糖摄取的方式调节全身糖代谢发挥抗糖尿病作用;CTRP12还可通过抑制巨噬细胞的炎症反应发挥非特异性抗炎作用;另外CTRP12可能有刺激胰岛β细胞促进胰岛素分泌的作用。
C1q / tumor necrosis factor-related protein 12 (CTRP12) is a recently discovered adipokine that is highly homologous to adiponectin and mainly acts on adipose tissue and liver. CTRP12 can also play an anti-diabetic role by regulating insulin signaling and directly activating the phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling pathway to inhibit gluconeogenesis and promote glucose uptake. By inhibiting the inflammatory response of macrophages play a non-specific anti-inflammatory effect; In addition CTRP12 may stimulate pancreatic β-cells to promote insulin secretion.