制备一种具有手性分离能力的毛细管电色谱整体柱并对丙谷胺对映体进行分离。以丙烯酰-β-环糊精(ACD)和甲基丙烯酸甘油酯(GMA)为功能单体,一步法制备ACD毛细管电色谱手性整体柱,并考察了该柱在制备过程中影响因素。通过红外(IR)、扫描电子显微镜(SEM)对其结构及形貌进行表征。利用该整体柱对手性药物丙谷胺对映体进行拆分并达到了基线分离。 A capillary column with monochromatographic separation was prepared and the propylamine enantiomer was separated. ACD and GMA were used as functional monomers to prepare ACD capillary chiral monolithic column by one-step method. The influencing factors of the column were also investigated. Its structure and morphology were characterized by infrared (IR) and scanning electron microscopy (SEM). The enantiomers of the chiral drugs promethazine were resolved using this monolithic column and baseline separation was achieved.