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目的:观察畅肺防喘方对哮喘豚鼠血浆cAMP、cGMP水平的影响。方法:用畅肺防喘方对卵蛋白致敏和攻击进行复制的过敏性哮喘豚鼠模型给药防治,并应用放射免疫的方法检测模型血浆cAMP、cGMP的水平。结果:畅肺防喘方能使模型血浆cAMP升高(P<0.01)、cGMP下降(P<0.01)。结论:畅肺防喘方在防治哮喘的动物实验中,对模型血浆cAMP、cGMP水平有明显的影响作用,并能提高其(cAMP/cGMP)比值。
Objective: To observe the effect of Changfei Fangchuan Formula on plasma cAMP and cGMP levels in asthmatic guinea pigs. METHODS: Allergic asthma guinea pigs models were sensitized and challenged with ovalbumin anti-asthma formula. The levels of cAMP and cGMP were measured by radioimmunoassay. RESULTS: Changfei Fangchuan can increase the plasma cAMP level (P<0.01) and cGMP (P<0.01). Conclusion: Changfei Fangchuan has significant effects on cAMP and cGMP levels in asthmatic animals, and can increase its cAMP/cGMP ratio.