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为研究苦瓜碱提多糖的降血糖功能,并分析它的降糖机理,分别对正常小白鼠和STZ诱导的糖尿病模型小鼠的降糖效果进行了比较,并对降糖机理进行初步分析。结果表明苦瓜碱提多糖400mg/kg的剂量可以显著降低正常小鼠和STZ糖尿病小鼠的血糖值,果糖胺的含量同样也有所降低。同时,苦瓜碱提多糖还可以提高糖尿病模型小鼠的葡萄糖耐量以及肝糖原的含量。苦瓜多糖的降糖机理可能是通过减弱STZ对胰岛β-细胞的损伤或改善受损β-细胞的功能,从而起到调节血糖的作用。
In order to study the hypoglycemic function of polysaccharide extracted from Bitter Melon and analyze its hypoglycemic mechanism, the hypoglycemic effects of normal mice and STZ-induced diabetic model mice were compared, and the hypoglycemic mechanism was analyzed. The results showed that the dose of 400 mg/kg of bitter melon alkaline polysaccharide can significantly reduce the blood glucose levels of normal and STZ diabetic mice, and the fructosamine content also decreased. At the same time, bitter melon alkaloid extraction can also improve glucose tolerance and hepatic glycogen content in diabetic model mice. The hypoglycemic mechanism of polysaccharides in Momordica charantia may be through regulating the function of STZ on islet β-cell damage or improving the function of damaged β-cells, thereby regulating blood glucose.