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目的:观察低分子肝素治疗急性早幼粒细胞白血病合并弥漫性血管内凝血(DIC)的疗效。方法:对30例确诊为急性早幼粒细胞白血病(APL)合并DIC的患者在治疗原发病及补充凝血因子的同时每日使用低分子肝素,另外30例作为对照组。结果:DIC纠正时间明显缩短,冷沉淀及血小板输注数目明显减少,而且无明显的副作用。结论:低分子肝素用于治疗APL合并DIC时安全有效,值得推广。
Objective: To observe the effect of low molecular weight heparin in the treatment of acute promyelocytic leukemia with diffuse intravascular coagulation (DIC). Methods: A total of 30 patients with acute promyelocytic leukemia (APL) and DIC were treated with low molecular weight heparin (LMWH) and 30 as control group. Results: DIC correction time was significantly shortened, the number of cryoprecipitate and platelet transfusion decreased significantly, and no obvious side effects. Conclusion: Low molecular weight heparin is safe and effective for the treatment of APL combined with DIC, which is worthy of promotion.