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目的探讨康莱特注射液联合三维适形放疗同步吉西他滨化疗治疗局部晚期胰腺癌的疗效。方法将 50 例局部晚期不可手术的胰腺癌随机分为治疗组( 25 例) 和对照组( 25 例) ,治疗组在吉西他滨联合同步三维适形放疗的基础上加用康莱特注射液( 100 mL/d) ,静脉滴注,连用 21 天,休息 1 周后第 28 天重复,用 2 个疗程。分别观察近期疗效、生存期、症状改善情况、肿瘤标志物及不良反应,为期 2 年。结果治疗组近期有效率( CR + PR) 52. 17% ( 12/23) ,稳定率( CR + PR + SD) 95. 65% ( 22/23) ,对照组有效率41. 67% ( 10 /24) ,稳定率 87. 50% ( 21 /24) ,差异无统计学意义( P > 0. 05) ; 治疗组 2 年生存率达 34. 78% ( 8 /23) ,优于对照组 25. 00% ( 6 /24) ; 治疗组中位生存期 17. 2 个月,对照组 12. 4 个月,两组比较,差异有统计学意义( P <0. 05) ; 患者疼痛症状的改善率与体重的增加率,治疗组分别为 75. 00% 和 82. 61%,与对照组[分别为 50. 00%和 54. 67%]比较,差异亦有统计学意义( P < 0. 05) ; 治疗后治疗组 CA19-9 与 CEA 分别降至( 118. 00 ±78. 89) U/mL、( 7. 41 ± 2. 37) ng/mL,与对照组[( 216. 00 ±153. 23) U/mL、( 12. 25 ± 7. 53) ng/mL]比较,差异有统计学意义( P < 0. 05) 。结论在三维适形放疗同步吉西他滨化疗的基础上加用康莱特注射液治疗局部晚期胰腺癌可取得更好的疗效。
Objective To investigate the curative effect of Kanglaite injection combined with three-dimensional conformal radiotherapy and simultaneous gemcitabine chemotherapy in the treatment of locally advanced pancreatic cancer. Methods Fifty patients with locally advanced unresectable pancreatic cancer were randomly divided into treatment group (25 cases) and control group (25 cases). The treatment group was treated with gemcitabine plus synchronous three-dimensional conformal radiotherapy plus Kanglaite injection (100 mL / d), intravenous infusion, once every 21 days, one week after the rest on the 28th day, with 2 courses. To observe the short-term efficacy, survival, symptoms, tumor markers and adverse reactions, for a period of 2 years. Results The effective rate (CR + PR) in the treatment group was 52.17% (12/23), the stability rate was 95.65% (22/23) in the CR + PR + SD group, / 24), the stability rate was 87.50% (21/24), the difference was not statistically significant (P> 0.05); The 2-year survival rate of the treatment group was 34.78% (8/23), which was better than that of the control group The median survival time of the treatment group was 17.2 months and that of the control group was 12.4 months. There was significant difference between the two groups (P <0.05). The pain symptom The improvement rate and weight gain rate in the treatment group were 75.00% and 82.61%, respectively, which were also significantly different from those in the control group (50. 00% and 54. 67% respectively) (P < 0.05). After treatment, the levels of CA19-9 and CEA decreased to (118.00 ± 78.89) U / mL and (4.41 ± 2.37) ng / mL, respectively, compared with the control group [(216. 00 ± 153. 23) U / mL, (12. 25 ± 7. 53) ng / mL], the difference was statistically significant (P <0.05). Conclusion Three-dimensional conformal radiotherapy combined with gemcitabine chemotherapy based on the addition of Kang Wright injection for the treatment of locally advanced pancreatic cancer can achieve better results.