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[目的]观察六味地黄丸对大鼠糖尿病肾病血糖、肌酐、尿素氮影响。[方法]使用随机平行对照方法,将48只昆明小鼠按随机数字表法分为对照组、实验组,24只/组。对照组生理盐水,灌胃,2mL/次,3次/d。实验组六味地黄丸浓缩丸,灌胃,1粒/次,3次/d。连续治疗56d为1疗程。观测大鼠血糖、肌酐、尿素氮。连续1疗程,判定疗效。[结果]血糖、肌酐、尿素两组均有改善(P<0.05),实验组改善优于对照组(P<0.05)。[结论]六味地黄丸对大鼠糖尿病肾病血糖、肌酐、尿素氮效果显著,值得推广。
[Objective] To observe the effect of Liuweidihuangwan on blood glucose, creatinine and urea nitrogen in rats with diabetic nephropathy. [Methods] Using randomized parallel control method, 48 Kunming mice were divided into control group, experimental group and 24 / group by random number table method. Control group, saline, gavage, 2mL / time, 3 times / d. Experimental group of Liu Wei Di Huang Wan concentrated pills, gavage, 1 / time, 3 times / d. Continuous treatment of 56d for a course of treatment. Blood glucose, creatinine and urea nitrogen were observed in rats. Continuous 1 course of treatment to determine the efficacy. [Result] The blood sugar, creatinine and urea were improved in both groups (P <0.05). The experimental group improved better than the control group (P <0.05). [Conclusion] Liuweidihuangwan has significant effects on blood glucose, creatinine and urea nitrogen in diabetic nephropathy, which is worth to be popularized.