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秋水仙碱为百合科植物丽江山慈菇的球茎中提取得到的一种生物碱,是一种传统的抗炎止痛药,也是一种有丝分裂毒素,可使细胞停止于分裂期,过去主要用于肿瘤及急性痛风性关节炎的治疗。近年来,临床应用进一步扩大,主要有以下见种。1 防治动脉粥样硬化 胆固醇仍被认为是动脉粥样硬化的主要致病因子之一,但当前用于治疗粥样硬化的多数药物仅着眼于抑制疾病的发展,而不影响胆固醇水平。Wojcicki等为研究秋水仙碱抗动脉粥样硬化的效果,将家兔分为3组进行实验发现,秋水仙碱具有明显的抗动脉粥样硬化的效果。作者认为,粥样硬化发生的病理机制在一定程度上犹如肿瘤的细胞增殖,可用于动脉粥样硬化的治疗.
Colchicine is one of the alkaloids extracted from the bulb of Pleurotus erythematosus, a traditional anti-inflammatory painkiller, is also a mitotic toxin that stops cells from dividing. In the past, it was mainly used in Tumor and treatment of acute gouty arthritis. In recent years, further expansion of clinical applications, mainly see the following species. 1 Prevention and Treatment of Atherosclerosis Cholesterol is still considered to be one of the major causative agents of atherosclerosis, but most drugs currently used to treat atherosclerosis focus only on inhibiting disease progression without affecting cholesterol levels. Wojcicki other in order to study colchicine anti-atherosclerotic effect, the rabbits were divided into three groups were found that colchicine has obvious anti-atherosclerotic effect. The author believes that the pathological mechanism of atherosclerosis to a certain extent, like tumor cell proliferation, can be used for the treatment of atherosclerosis.