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目的分析深圳市大鹏新区实施乙肝疫苗免疫策略后乙肝血清流行病变化。方法采取整群随机抽样调查方法,在深圳市大鹏新区抽取1~20岁年龄段的人群1 000例,分析实施乙肝疫苗免疫策略前后乙肝血清病学变化。结果实施乙肝疫苗免疫策略后,1~20岁人群HBsAg阳性率为1.21%,不同年龄段比较差异无统计学意义(P>0.05);Anti-HBs阳性率为72.17%,不同年龄段比较差异有统计学意义(P<0.01),Anti-HBc阳性率为2.33%,不同年龄段比较差异有统计学意义(P<0.01);男、女HBsAg、Anti-HBs、Anti-HBc阳性率分别为1.04%、70.10%、2.49%及1.40%、74.16%、2.17%,不同性别之间比较差异无统计学意义(P>0.05);实施后HBsAg、Anti-HBc阳性率明显低于实施前(1.21%vs.5.71%、2.33%vs.12.68%),Anti-HBs阳性率明显高于实施前(72.17%vs.21.96%)。结论深圳市大鹏新区1~20岁人群实施乙肝疫苗免疫策略后乙肝血清流行病变化有助于建立较高的免疫屏障。
Objective To analyze the change of hepatitis B seroprevalence after implementing Hepatitis B vaccine immunization strategy in Shenzhen Dapeng New District. Methods Randomized cluster sampling method was used to select 1 000 cases of 1 ~ 20 years old population in Dapeng New District of Shenzhen City. The serological changes of hepatitis B before and after the hepatitis B vaccine immunization strategy were analyzed. Results The HBsAg positive rate was 1.21% in the population aged 1 ~ 20 years after the implementation of the hepatitis B vaccine immunization strategy. There was no significant difference in different age groups (P> 0.05). The positive rate of Anti-HBs was 72.17% (P <0.01). The positive rate of Anti-HBc was 2.33%, the difference was statistically significant in different age groups (P <0.01). The positive rates of HBsAg, Anti-HBs and Anti-HBc in male and female were 1.04 (P> 0.05). The positive rates of HBsAg and Anti-HBc after the implementation were significantly lower than those before the implementation (1.21% vs.5.71%, 2.33% vs.12.68%). The positive rate of Anti-HBs was significantly higher than before (72.17% vs.21.96%). Conclusion The changes of hepatitis B seropositivity after 1 ~ 20 years old population in Dapeng New District of Shenzhen City for implementing hepatitis B vaccination strategy may help to establish a higher immune barrier.