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IgA肾病(IgA nephropathy,IgAN)由Berger和Hinglais于1968年首次提出的一种全球范围内最常见的原发性肾小球疾病,又称Berger’s病。以血尿为主要临床表现,可伴有不同程度的蛋白尿、高血压和肾功能受损,病理以弥漫性肾小球系膜细胞和基质增多、系膜区IgA为主的免疫球蛋白及其复合物颗粒样沉积为主要特点。
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide, also known as Berger’s disease, first proposed by Berger and Hinglais in 1968. Hematuria as the main clinical manifestations may be associated with varying degrees of proteinuria, hypertension and impaired renal function, pathological diffuse glomerular mesangial cells and matrix increased, mesangial IgA-based immunoglobulin and its Composite particle-like deposits as the main feature.