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目的探讨他汀类及抗血小板药物对脑卒中及短暂性脑缺血(TIA)患者的干预作用。方法选择73例,缺血性脑血管病合并颈动脉粥样硬化患者。将其随机分为治疗组和对照组。治疗组37例,应用阿托伐他汀(80mg/d)和阿司匹林(100g/d)。对照组36例,仅给阿司匹林(100mg/d)共随访2年。同时分别在治疗前,治疗后检测血脂,测定颈动脉狭窄程度,颈动脉斑块积分。结果治疗组平均颈动脉狭窄程度和颈动脉斑块积分明显高于治疗前,具有统计学意义(P<0.01)。治疗组对脑卒中及短暂性脑缺血病复发率与对照组复发率相比明显下降。结论联合应用他汀类及抗血小板药能延缓和逆转脑卒中患者颈动脉粥样硬化的进展,对脑卒中及短暂性脑缺血的脑血管病的复发有很好的预防作用。
Objective To investigate the intervention effects of statins and antiplatelet drugs on patients with stroke and transient cerebral ischemia (TIA). Methods 73 cases of patients with ischemic cerebrovascular disease combined with carotid atherosclerosis. They were randomly divided into treatment group and control group. Treatment group of 37 cases, the application of atorvastatin (80mg / d) and aspirin (100g / d). Control group, 36 cases, only to aspirin (100mg / d) were followed up for 2 years. At the same time, respectively, before treatment, after treatment, detection of lipid, carotid artery stenosis, carotid plaque score. Results The mean carotid artery stenosis and carotid plaque score in the treatment group were significantly higher than those before treatment (P <0.01). The treatment group of stroke and transient ischemic attack recurrence rate compared with the control group decreased significantly. Conclusions The combination of statins and antiplatelet drugs can delay and reverse the progression of carotid atherosclerosis in stroke patients and prevent the recurrence of cerebrovascular diseases such as stroke and transient ischemic attack.