论文部分内容阅读
应用肿瘤细胞花环法（ECR1CaR）对肺癌患者的红细胞CR1活性进行了检测，并比较肺癌组与正常对照组红细胞、白细胞免疫功能改变。结果显示：肺癌组红细胞CR1活性明显降低，红细胞CR1活性抑制因子明显增高，但促进因子显著降低；肺癌组红细胞CR1活性抑制因子与血清SIL-2R改变呈中度相关；Ⅳ期肺癌患者红细胞CR1活性及CD4+／CD8+比值明显低于Ⅱ、Ⅲ期肺癌患者，而SIL-2R却明显高于Ⅱ、Ⅲ期肺癌患者。表明红细胞CR1活性及其调节因子水平是研究肺癌病情的重要指标。
Erythrocyte CR1 activity was detected in patients with lung cancer using ECR1CaR, and the immune function of red blood cells and white blood cells was compared between lung cancer and normal controls. The results showed that the activity of CR1 in erythrocytes of lung cancer group was significantly decreased, and the inhibitory factor of CR1 activity in erythrocytes was significantly increased, but the promoting factor was significantly decreased. The CR1 activity inhibitory factor in erythrocytes of lung cancer group was moderately correlated with the change of serum SIL-2R; the CR1 activity of erythrocyte in patients with stage IV lung cancer. The CD4+/CD8+ ratio was significantly lower than that of stage II and III lung cancer patients, but SIL-2R was significantly higher than those of stage II and III lung cancer patients. It shows that the activity of red blood cell CR1 and its regulatory factors are important indicators for the study of lung cancer.