临床应用抗菌药物治疗的目的是清除病原菌以获得最大疗效,同时防止细菌耐药性的产生。为了达到这个目的需要正确理解药代动力学(药动学)和药效动力学(药效学)原理,并将药动学和药效学结合起来。近年来对抗菌药物PK/PD与给药方案设计相关性的研究,已成为抗感染领域关注的热点。 Clinical Applications The purpose of antimicrobial therapy is to clear the pathogen for maximum efficacy while preventing bacterial resistance. To achieve this goal, a correct understanding of pharmacokinetics (pharmacokinetics) and pharmacodynamics (pharmacodynamics) principles is required, and pharmacokinetics and pharmacodynamics are combined. In recent years, the research on the correlation between antimicrobial PK / PD and drug delivery design has become a hot topic in anti-infective field.