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目的探讨中药活化克岩酊抗炎镇痛的作用效果,为临床提供可靠的实验数据。方法取小鼠随机分成4组,11～12只/组。模型对照组外用同体积的生理盐水,阳性对照组外用正红花油,实验高浓度组和低浓度组外用100%和60%的中药活化克岩酊,将二甲苯涂于各组小鼠右耳致炎;腹腔注射醋酸溶液致痛使其产生扭体反应;将小鼠置于药理热板仪中,调节温度55℃,观察记录小鼠在不同时间段内接触热板至舔后足的时间。结果中药活化克岩酊对二甲苯致炎的小鼠耳肿胀具有明显的抑制作用,同时能显著抑制小鼠扭体反应的发生率和延长小鼠添足反应的的潜伏期。结论实验研究表明,中药活化克岩酊具有较强的抗炎镇痛作用。
Objective To investigate the anti-inflammatory and analgesic effect of traditional Chinese medicine activated Ke Yan tincture and provide reliable experimental data for clinical practice. Methods The mice were randomly divided into 4 groups, 11 ~ 12 / group. The model control group was treated with the same volume of normal saline and the positive control group with external safflower oil. The experimental high concentration group and the low concentration group were topically treated with 100% and 60% Ear inflammation caused by intraperitoneal injection of acetic acid solution caused writhing reaction; the mice were placed in pharmacological hot-plate instrument, the temperature was adjusted at 55 ℃, the observation of mice in different time periods contact with the hot plate to lick the hind foot time. Results Activation of Ke Yan tincture of xylene induced inflammatory ear swelling in mice significantly inhibited the same time, significantly inhibited the incidence of writhing in mice and prolonged the latency of the mouse to add foot response. Conclusion Experimental studies show that Chinese medicine activated grams of tincture has a strong anti-inflammatory analgesic effect.