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目的了解广东省深圳市淋病双球菌对抗生素的耐药性及产β内酰胺酶淋病双球菌(PPNG)和高水平耐四环素淋病双球菌(TRNG)的流行状况。方法采用琼脂稀释法测定5种抗生素对240株淋病双球菌的最低抑菌浓度(MIC);用改良碘定量法检测PPNG菌株。结果淋病双球菌对青霉素、四环素、环丙沙星及头孢三嗪的耐药率分别为71.67%,78.33%,37.50%及6.67%;检出32株PPNG菌株,占13.33%;检出30株TRNG菌株占12.5%;同时对青霉素、四环素、环丙沙星耐药的菌株占31.67%。结论壮观霉素、头孢三嗪仍可作为深圳市治疗淋病的首选用药,但淋球菌对四环素及青霉素的耐药率较高。
Objective To investigate the antibiotic resistance and the epidemic situation of Streptococcus gondii in Shenzhen City, Guangdong Province, producing β-lactamase-producing gonorrhea (PPNG) and high-level tetracycline-resistant gonorrhea (TRNG). Methods The minimum inhibitory concentration (MIC) of five antibiotics against 240 strains of Gonorrhea was determined by agar dilution method. PPNG strains were detected by modified iodine method. Results The rates of resistance to penicillin, tetracycline, ciprofloxacin and ceftriaxone in Gonorrhea were 71.67%, 78.33%, 37.50% and 6.67%, respectively. 32 strains of PPNG were detected, accounting for 13.33% TRNG strains accounted for 12.5%; at the same time penicillin, tetracycline, ciprofloxacin resistant strains accounted for 31.67%. Conclusion Spectinomycin and ceftriaxone can still be used as the first choice for the treatment of gonorrhea in Shenzhen. However, the rates of resistance to tetracycline and penicillin in Neisseria gonorrhoeae are high.