目的 :研究神经生长因子 (NGF)在小鼠体内的动力学、组织分布和排泄情况。 方法 :采用核素标记结合电泳法测定小鼠肌注 1 2 5 I- NGF后不同时间体液及组织中 NGF含量。结果 :肌注后血浆药 -时曲线符合二室分布模型 ,消除半衰期 (t1 /2β)为3.1h,分布半衰期 (t1 /2 kα)为 5 m in,最高吸收峰时间为 2 5 min,AU C为 72 .4mg· kg- 1· h- 1。甲状腺、血浆、颌下腺、颈上神经节、肾上腺素和肾脏中药物浓度较高。 结论 :NGF在体内分布广 ,组织内含量高 ,主要通过尿液排泄 Objective: To study the kinetics, tissue distribution and excretion of nerve growth factor (NGF) in mice. Methods: The content of NGF in body fluids and tissues at various time after intramuscular injection of 125 I-NGF was determined by radionuclide labeling combined with electrophoresis. Results: The plasma drug-time curve after intramuscular injection conformed to the two-compartment model. The elimination half-life (t1 / 2β) was 3.1h, the half-life of distribution (t1 / 2 kα) was 5 min and the peak time was 25 min. C is 72.4 mg · kg -1 · h -1. Thyroid, plasma, submandibular gland, superior cervical ganglion, epinephrine and kidney drug concentrations higher. Conclusion: NGF is widely distributed in the body and has high content in tissues, which is mainly excreted through the urine