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目的探讨血清胆碱酯酶(ChE)活性在肝脏疾病中的应用及临床意义。方法采用酶速率法对216例肝病患者及44名正常健康体检者进行血清ChE活力测定。结果各类肝病组血清ChE活性均降低,与正常对照组比较,差异有显著(P<0.05);肝硬化组与另外3组肝病比较,差异有显著(P<0.05)。血清ChE活性降低程度与肝细胞损害程度相平行。结论血清ChE的活性降低程度与肝病病情严重程度关系密切,血清ChE活性的动态观察可作为判断肝病严重程度和预后的一个重要指标。
Objective To investigate the clinical application of serum cholinesterase (ChE) activity in liver diseases. Methods Serum ChE activity was measured in 216 patients with liver disease and 44 healthy controls by enzymatic rate method. Results Serum ChE activity was decreased in all kinds of liver disease group, compared with the control group, the difference was significant (P <0.05). There was significant difference (P <0.05) between the liver cirrhosis group and the other three groups. Serum ChE activity decreased degree of liver cell damage in parallel. Conclusion The decrease of serum ChE activity is closely related to the severity of liver disease. The dynamic observation of serum ChE activity can be used as an important index to judge the severity and prognosis of liver disease.