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目的观察小梁切除术联合同种异体羊膜植入和术眼球结膜下注射干扰素α-2b治疗顽固性青光眼的疗效。方法对23例(23只眼)顽固性青光眼行小梁切除术联合羊膜移植于巩膜床,分别于术时、术后1d、3d、7d、14d术眼球结膜下注射干扰素α-2b 50万单位。术后随访15~25个月,平均18.5个月。观察术后阻止瘢痕性滤过泡形成的效果、降眼压作用、手术成功率及视力变化。结果23只眼中,形成功能性滤过泡20只眼,无功能滤过泡3只眼,术后6个月眼压从术前的(36.42±5.64)mmHg降低到(15.73±2.99)mmHg(t=11.465,P<0.01)。术后24个月末,手术的成功率为65.8%(寿命表法)。结论小梁切除术联合羊膜植入与干扰素α-2b注射能提高成功率,且安全、可靠。
Objective To observe the effect of trabeculectomy combined with allogeneic amniotic membrane implantation and intraocular subconjunctival injection of interferon α-2b in patients with refractory glaucoma. Methods Twenty-three patients (23 eyes) with intractable glaucoma underwent trabeculectomy combined with amniotic membrane transplantation in the scleral bed were injected subcutaneously with 500,000 interferon α-2b at the time of operation, 1 day, 3 days, 7 days and 14 days after operation. unit. The patients were followed up for 15-25 months with an average of 18.5 months. To observe the effect of preventing cicatricial filtration bleb formation, lowering intraocular pressure, success rate of surgery and visual acuity. Results In 23 eyes, there were 20 eyes with functional bleb and 3 eyes without functional bleb. The intraocular pressure decreased from 36.42 ± 5.64 mmHg to 15.73 ± 2.99 mmHg at 6 months after operation t = 11.465, P <0.01). At the end of 24 months, the success rate of surgery was 65.8% (life table method). Conclusion Trabeculectomy with amniotic membrane transplantation and interferon α-2b injection can improve the success rate, and safe and reliable.