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目的探讨高血压病中D－Ⅱ聚体（DD）的临床意义。方法用ELISA法测定高血压病Ⅱ－Ⅲ期159例患者的DD。结果高血压病Ⅱ期不同性别中DD含量比较及高血压Ⅱ期与正常对照组DD含量比较均无差异（P＞0．05）。急性脑梗塞、多发性脑梗塞后与正常对照组DD含量比较有显著差异（P＜0．01）。急性脑梗塞组与陈旧性脑梗塞DD含量比较有显著差异（P＜0．01）。急性脑出血、陈旧性脑出血与正常对照组DD含量比较有显著差异（P＜0．01），而急性脑出血与陈旧性脑出血DD含量比较无差异（P＞0．05）。腔隙性脑梗塞与正常对照组DD含量比较无差异（P＞0．05）。结论测定高血压患者DD有助于血栓性疾病的早期诊断，对判断疗效，预后的估计有一定意义。
Objective To investigate the clinical significance of D-dimer (DD) in hypertension. Methods The DD of 159 patients with stage Ⅱ-Ⅲ hypertension was measured by ELISA. Results There was no significant difference in DD content between hypertensive patients with stage Ⅱ and DD between hypertensive phase Ⅱ and normal controls (P> 0.05). Acute cerebral infarction, multiple cerebral infarction and normal control group DD content was significantly different (P <0.01). Acute cerebral infarction group and old cerebral infarction DD content were significantly different (P <0.01). The levels of DD in acute cerebral hemorrhage, old cerebral hemorrhage and normal control group were significantly different (P <0.01), while there was no difference in the content of DD between acute intracerebral hemorrhage and old intracerebral hemorrhage (P> 0.05). There was no difference in DD content between lacunar infarction and normal control group (P> 0.05). Conclusions The determination of DD in hypertensive patients is helpful for the early diagnosis of thrombotic diseases, which is of certain significance in judging the efficacy and prognosis.