代谢组学的原理是通过机体的动态代谢途径研究各种生命现象及其机制。目前,其已成为一种新的研究机体代谢产物谱变化的系统方法。其中,以人体代谢网络末端产物——尿液作为研究对象的尿液代谢组学,以其无创、标本易于获取的特点而成为当前极具发展潜力的重要分支。代谢组学现已在以阿尔茨海默病、帕金森病为代表的神经变性疾病的早期诊断和机制探索中得到了应用,本文即对该 The principle of metabonomics is the study of various life phenomena and their mechanisms through the body’s dynamic metabolic pathways. At present, it has become a new systematic method to study the change of body metabolite spectrum. Among them, the urine metabolomics, which is the end product of the human metabolic network - urine, is an important branch with great potential for development due to its non-invasive and easy-to-obtain samples. Metabonomics has now been applied in the early diagnosis and mechanism exploration of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.