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文献表明,美国一些接受阳光最少的地区,结肠癌的死亡率最高;饮食中中等量的维生素D(VD),>150IU/天,可降低结肠癌的发生率;强致癌剂处理大鼠,VD 使其结肠肿瘤的发生率几乎下降一半;人结肠癌细胞有1,25-(OH)_2VD 受体;VD 代谢产物在体外实验抑制人结肠癌细胞;1,25-(OH)_2VD 可使肿瘤体内转移灶消退。本研究目的是了解血清25-OHVD 浓度与随后8年结肠癌发生率的关系。1974年9月至11月,在马里兰州华盛顿县采集25620名志愿者的血样,取血清于-73℃保存。在随后8年(1975年1月1日～1983年12月
According to the literature, some regions in the United States that receive the least sunshine have the highest mortality rate of colon cancer; moderate amounts of vitamin D (VD) in the diet, >150 IU/day, can reduce the incidence of colon cancer; rats with strong carcinogen treatment, VD The incidence of colon cancer is reduced by almost half; human colon cancer cells have 1,25-(OH)_2VD receptors; VD metabolites inhibit human colon cancer cells in vitro; 1,25-(OH)_2VD can make tumors In vivo metastasis fades. The purpose of this study was to understand the relationship between serum 25-OHVD concentrations and the incidence of colorectal cancer in the following 8 years. From September to November 1974, blood samples were collected from 25,620 volunteers in Washington County, Maryland and serum was stored at -73°C. In the following 8 years (January 1, 1975 to December 1983)