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目的探讨原发性高血压患者动态动脉硬化指数(ambulatory arterial stiffnessindex,AA-SI)与早期肾损害的相关性。方法 150例原发性高血压患者利用24h动态血压监测数据计算AASI,同时测定24h尿微量白蛋白(microalbuminuria,MAU)。根据MAU结果分为MAU升高组与MAU正常组,比较两组各参数指标的差异,并对各参数进行Pearson相关性分析。结果 MAU升高组与MAU正常组相比较,AASI明显升高(P<0.05)。同时相关性分析显示AASI与MAU存在正相关关系(r=0.34,P<0.01)。结论原发性高血压患者AASI增加与早期肾损害相关。
Objective To investigate the correlation between ambulatory arterial stiffness index (AA-SI) and early renal damage in patients with essential hypertension. Methods AASI was calculated using ambulatory blood pressure monitoring data from 150 patients with essential hypertension and 24h microalbuminuria (MAU) was measured. According to the results of MAU, the subjects were divided into MAU elevation group and MAU normal group, and the differences of the indexes of the two groups were compared. The Pearson correlation analysis of each parameter was made. Results Compared with normal MAU group, AASI increased significantly in MAU elevated group (P <0.05). Correlation analysis showed that there was a positive correlation between AASI and MAU (r = 0.34, P <0.01). Conclusion The increase of AASI in patients with essential hypertension is associated with early renal damage.