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采用 Brd U- Giemsa染色法检测了湖南湘潭地区居民中有咀嚼槟榔习惯的口腔粘膜下纤维性变 (OSF)患者2 7人 ,有咀嚼槟榔习惯但未患 OSF的健康者 14人 ,无咀嚼槟榔习惯的正常人 44名的外周血淋巴细胞姐妹染色单体交换率 (SCE率 )。结果显示 :有咀嚼槟榔习惯者 SCE频率显著高于无咀嚼槟榔习惯者 (P<0 .0 0 1) ;患 OSF者SCE频率显著高于健康者 (P<0 .0 0 1)。此研究提示了槟榔咀嚼物中含有某些致突变或恶变成份 ,咀嚼槟榔习惯可严重影响染色体的稳定性 ;OSF为一种癌前状态 ,其发生可能具有一定的遗传背景或易感性
BrdU-Giemsa staining was used to detect 27 patients with oral submucous fibrosis (OSF) who habitually chew betel nut in Xiangtan, Hunan Province. There were 14 healthy betel nut chewing but no OSF, The habit of normal 44 people with peripheral blood lymphocytes sister chromatid exchange rate (SCE rate). The results showed that the frequency of SCE in chewing betel nut habit was significantly higher than that in non-chewing betel nut habitants (P <0.01). The frequency of SCE in OSF patients was significantly higher than that in healthy volunteers (P <0.01). This study suggests that betel nut chewing contains some mutagenic or malignant components, chewing betel nut habit can seriously affect the stability of the chromosome; OSF is a precancerous state, its occurrence may have a certain genetic background or susceptibility